Medicenna Announces Preclinical Data on MDNA11 with Anti-PD-1 Therapy and Unveils Novel Bifunctional Superkines at the Cytokine-Based Cancer Immunotherapies Summit
-- MDNA11 and anti-PD-1 combination leads to complete responses in a murine solid tumor model
-- Preclinical data demonstrates the potential of BiSKITsTM (Bi-functional SuperKine ImmunoTherapies) to effectively target immunologically “cold” tumors
The presentation will feature preclinical data on MDNA11, a long-acting IL-2 Superkine that preferentially binds the IL-2 beta receptor (IL-2Rβ) on immune cells, as well as an overview of Medicenna’s Bi-functional SuperKine ImmunoTherapies (BiSKITsTM) program, which includes engineered interleukins designed to target immunologically “cold” tumors.
“Immunosuppressive tumor microenvironments (TMEs) often limit the efficacy of checkpoint inhibitors, highlighting an unmet need for new therapeutic agents that can induce an anti-cancer immune response and overcome immunotherapy resistance mechanisms,” said
The oral presentation, titled “Designer Cytokines” will be given by
Highlights from the presentation include:
- Treatment with MDNA11 alone or in combination with anti-PD-1 therapy led to tumor growth inhibition and complete responses in a murine MC38 tumor model. Tumor growth was not inhibited by anti-PD-1 monotherapy.
- Preclinical data demonstrate the ability of MDNA413, an IL-13 super-antagonist, to suppress myeloid derived suppressor cells (MDSC) and M2a polarization of tumor associated macrophages, which are known to accumulate in the TME and promote cancer growth.
- A novel DUal CytoKine asset (DUCK CancerTM) designed to simultaneously stimulate a pro-inflammatory, anti-cancer (Th1) response through IL-2 activation while inhibiting IL-4/IL-13 signaling to suppress the anti-inflammatory (Th2) response is described. Data on the IL-2/IL13 DUCK will be presented next month at the AACR Annual Meeting 2021.
A copy of slides from the oral presentation will be posted to the “Events and Presentations” page of Medicenna’s website.
Medicenna is a clinical stage immunotherapy company focused on the development of novel, highly selective versions of IL-2, IL-4 and IL-13 Superkines and first in class Empowered Superkines for the treatment of a broad range of cancers. Medicenna's long-acting IL2 Superkine asset, MDNA11, is a next-generation IL-2 with superior CD122 binding without CD25 affinity and therefore preferentially stimulates cancer killing effector T cells and NK cells when compared to competing IL-2 programs. Medicenna's lead IL4 Empowered Superkine, MDNA55, has completed a Phase 2b clinical trial for rGBM, the most common and uniformly fatal form of brain cancer. MDNA55 has been studied in five clinical trials involving 132 subjects, including 112 adults with rGBM. MDNA55 has obtained Fast-Track and Orphan Drug status from the FDA and FDA/EMA, respectively.
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